2005 Symposium on Advanced Wound Care | |
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Laboratory Research
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Assessment of antimicrobial activity of wound dressings. D.W. Brett, BS, BS, MS, Smith & Nephew, Largo, FL; Donald A. Hendrickson, PhD, Katie Bilger, BS, Keri Nixon, BS, Hoosiers Microbiological Laboratory, Muncie, IN As new and innovative wound dressings are introduced to the public it becomes important to determine their antimicrobial activity and compare them with preexisting treatments. But how is this done? In vitro analysis is one way. In this study the antimicrobial properties of several silver coated dressings were examined in vitro with the log reduction test method (in triplicate). The AgCl and Ag/Carbon dressing did not have much of a reduction for any of the bacteria tested. The AgCMC/AgCl, Ag/PO4 and Ag/NH4 dressings did not have much of a reduction for MRSA and VRE. The Metallic silver dressing did not have much of a reduction for MRSA. A two hour incubation for the AgCMC/AgCl and Ag/NH4 did not increase the destruction PA, MRSA or VRE. This study demonstrated that nanocrystalline silver coated dressing exhibited greater antimicrobial activity than any of the other silver coated topical wound care dressings studied. These results are in agreement with previous studies that included clinically significant antibiotic resistant bacteria. Although AgCMC/AgCl and SSD produced a four log reduction of PA they did not give a four log reduction of MRSA or VRE. References Yin HQ, Langford R, Burrell RE. Comparative evaluations of the antimicrobial activity of Acticoat antimicrobial barrier dressing. J Burn Care Rehabil. 1999;20:195–200. |
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