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Clinical Research
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A prospective cohort analysis of Indian Health Services chronic wound patients treated with autologous platelet rich plasma gel John Farris, Gloria Holder, Pat Justice Objective: To evaluate the wound healing outcomes in chronic wound patients treated with autologous platelet-rich plasma gel* (PRP) in the Oklahoma City Service Area of the Indian Health Service. The healing outcomes using PRP were compared with previous outcomes using traditional, standard of care practices Materials and Methods: A Chronic Wound Management Educational Initiative was conducted at 5 Indian Health Service sites. A certified wound specialist nurse worked with the physicians and staff. Education, mentoring, and data gathering were provided along with access to an advanced therapy, autologous platelet-rich plasma gel. Predetermined criteria were identified for wounds to be treated with this therapy. Data was gathered prospectively and entered into a Wound Registry. Upon initiative completion, the data were analyzed and compared to previous outcomes Results: Thirty five (35) patients with 46 wounds of various etiologies met the criteria and were treated with the PRP. Forty-two of 46 wounds (91%) healed in an average of 9.8 weeks. These wounds had been non-healing for an average of 23.5 weeks previously. Per etiology wound healing was as follows: venous ulcers-10/12 (83%); diabetic ulcers- 8/9 (89%); dehiscence 11/11 (100%); trauma wound 1/1 (100%); insect bites 4/4 (100%); pressure ulcers 2/2 (100%); collagen vascular disease 2/2 (100%); and other wounds 4/5 (80%). Weeks to healing with PRP vs previous weeks with non-healing were: venous ulcers- 8 vs 90.2; diabetic ulcers-11.3 vs 12.4; dehiscence-18 vs 20.2; insect bites-6 vs 5.8; pressure ulcers-12.5 vs 13; collagen vascular disease-8 vs 34, trauma 5.6 vs 5; and other wounds 9.2 vs 7.2 Conclusion: Using this PRP resulted in increased healing and a shorter period to heal for the majority of the wound patients participating in this wound care initiative *Product Notation: AutoloGelª , Cytomedix, Inc, Rockville, MD |
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