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Laboratory Research
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Using keratin biopolymer materials for wound treatment Robert Allen Smith, Keraplast Technlologies Ltd; Fertram Sigurjonson, Rob Kelly, Keratec Limited; .Azam Ali, Canesis Network Ltd; Rob McPherson, University of Queensland. Keratin protein is one of nature's most abundant materials, and the major component of the outermost layer of the skin. In a wound environment the keratinized layer of the skin is highly compromised. Wound treatments often attempt to create a favourable environment in the wound bed and encourage the healing process. Biopolymers are well known to provide a favourable environment for wound healing, however, to date biopolymers derived from keratin protein have not been applied for the treatment of wounds. In this study the problem of creating a favourable environment for wound healing was addressed through the use of novel keratin biopolymer materials. Substantial advances in keratin protein science have lead to the development of keratin protein biopolymer products suitable for application to a range of wound types. The suitability of these novel materials was initially determined through in vitro studies. Cellular response to keratin biopolymers were very favourable when measured in vitro across a range of cell types important to the healing wound. Further research determined the effect of applying keratin biopolymers to partial and full thickness wounds in animal models, specifically mouse and pig. Animal trial data demonstrated accelerated healing for wounds treated with keratin based dressings when compared to commercially available dressings. Histological examination revealed in an increase in the rate of epithelialization and advanced wound maturation for the keratin treated group in both animal models Keratin clearly creates a favourable environment for the healing wound. Further development is being undertaken to develop this promising new biopolymer material. |
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