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Clinical Research
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Oasis wound matrix versus hyaluronic acid in the treatment of difficult-to-heal wounds of mixed arterial/venous aethiology M. Romanelli, V. Dini, C. Brilli, M. Bertone, Wound Healing Research Unit, Department of Dermatology, University of Pisa, Pisa, Italy Introduction.Wounds with mixed arterial/venous (A/V) aethiology are notoriously difficult to heal and generally are not candidates for compression therapy. These wounds are unable to support timely development of an extracellular matrix, capillary ingrowth, and the cellular proliferation needed for healing Materials and Methods.In this study, we compared the effects of Oasis Wound Matrix versus hyaluronic acid wound dressing* for the treatment of mixed A/V ulcers. Oasis is an active biomaterial that comprises both growth factors and extracellular matrix components such as collagen, proteoglycans, and glycosaminoglycans. Patients (n = 54) were randomized to treatment with Oasis or hyaluronic acid dressing for 16 weeks. We evaluated the percentages of patients achieving complete wound closure within 16 weeks, mean time to dressing changes, patient comfort during treatment and at dressing change, and pain. Results.By the end of the 16-week study, 82.6% of wounds treated with Oasis had healed completely, compared with 46.2% of wounds treated with hyaluronic acid (P < 0.001). The mean time between dressing changes was 6.4 days in the Oasis-treated group compared with 2.4 days in the hyaluronic acid-treated (P < 0.05). Additionally, Oasis was associated with higher levels of patient comfort and reduced pain compared to hyaluronic acid (P < 0.05). Conclusions.Overall, this study found that Oasis was superior to hyaluronic acid for the treatment of patients with mixed A/V ulcers, a population in which standard treatment options largely consist of moist wound dressings. *Hyaloskin, FAB, Abano Terme, Italy |
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