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Laboratory Research
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The deposition of silver into human skin Mike Walker, Christine Cochrane, Chris Rhuland, Geoff Newman, Phil Bowler, ConvaTec Wound Therapeutics, Deeside, Flintshire, UK The application of some silver dressings to wound tissue and the surrounding peri-ulcer skin has been shown to result in transient skin staining1. In these studies, a silver-containing Hydrofiber¨ dressing (SCH) and a silver-containing nanocrystalline (SCNC) dressing were applied to human skin (epidermis and dermis) and dermal membranes (to mimic a wound environment, ie, with no epidermal barrier present) to investigate their potential for silver deposition. Results for the SCNC dressing showed that there was substantial deposition of silver in the stratum corneum and superficial layers of the epidermis, while in the dermis silver was seen to have accumulated to depths of >100µm. In contrast, following application of the SCH dressing silver deposition remained superficial and was confined to the outer layers of the stratum corneum. Similarly, in the dermis there was minimal evidence of silver deposition on the dermal surface with no silver deposited in the papillary dermis. Walker M, Cochrane CA, Bowler PG, Parsons D, Bradshaw P. Silver deposition and tissue staining associated with silver-containing wound dressings. Ostomy Wound Manage. 2006;52(1):42Ð50. |
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