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Oral Abstracts (Session 5 of 5)
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Moderator: David Keast, MSc, MD, CCFP, FCFP (Presentation 36.5) A novel fetal bovine dermal matrix scaffold is rapidly incorporated into animal and human wounds resulting in wound bed stimulation Thomas E. Serena, MD, FACS, NewBridge Medical Research and Penn North Centers for Advanced Wound Care, Warren, Pa Background: Pre-clinical animal studies with a fetal bovine dermal collagen matrix suggest that fibroblasts and new blood vessels quickly populate the material. Experience with bioengineered skin constructs and porcine small intestinal submucosal products suggest that the application of a scaffold or matrix may play a role in stimulating healing. Methods: A fetal bovine dermal collagen matrix was applied to patients with long-standing venous leg ulcerations. Histologic examination pre and post application with trichrome staining was employed to differentiate matrix from native collagen. Comparisons between animal and human ulcers were made grossly and histologically. Results: In all patients, there was rapid formation of granulation tissue with a decrease in the depth of the wound. The stimulatory effect persisted for approximately 1 month after which time a second matrix was applied. In contrast to the animal study, the grafts exhibited “take” in only 1 of our patients. Histologic examination in both animals and humans suggests a stimulation of native collagen production as well as an initial incorporation of the scaffold into the wound bed. Conclusion: The product may function as a scaffold for the in-growth of cells essential to wound healing. Further investigation in a randomized, controlled study setting is recommended. |
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