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Oral Abstracts (Session 4 of 5)
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(Presentation 35.2) The use of an acellular dermal regenerative tissue matrix in the treatment of diabetic foot ulcers: a 17-week analysis Steve Brigido, DPM, Foot and Ankle Center at Coordinated Health Wound management of ulcers in the diabetic foot can often present challenging and complex problems. Approximately 15% of the diabetic population will be afflicted with these slow-to-heal, frequently recurrent ulcers at some point in their lifetime. These ulcers remain the primary cause of hospitalizations for all patients with diabetes. The purpose of this evaluation was to observe the effectiveness of a human acellular regenerative tissue matrix as a treatment option for chronic nonhealing lower-extremity wounds. A total of 14 patients with diabetes and full-thickness wounds that had been present for at least 6 weeks were treated with sharp debridement and a single application of the regenerative tissue matrix. A mineral oil soaked fluff compressive dressing was then applied. All patients were seen weekly. By Week 17, 12 of 14 (85.7%) patients treated with the tissue matrix demonstrated complete healing as defined by complete epithelization. Patients treated with the tissue matrix showed a high percentage of wound healing with respect to wound area, wound depth, and wound volume. This study demonstrates that the use of this human acellular regenerative matrix in conjunction with sharp debridement can be a beneficial modality of treatment for lower-extremity ulcers. |
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